The only other major change to talk about is the inclusion of the new "Puzzle Randomization" feature. Starting a new game gives you the choice of two types of puzzle: "Classic", i.e. how they were in the original game, and "Randomized". Don't get carried away, though. Despite how it might sound, the Randomized option does not suddenly turn Myst into a rogue-like, you will not be riding the Mazerunner in the Stoneship Age. Instead, it simply changes the solutions to each puzzle like, for example, the number of volts you'd need to power the rocket to Selenitic. The only Age that's pretty much unaffected is Channelwood, with the exception of one thing, and since I don't know how to mark spoilers here, let's just say if you've played Myst before, then we're on the same page.
Overall, even if you've already played a previous version of Myst, even if you don't have a VR set, I would HIGHLY recommend giving this new iteration a try. I ended the aforementioned wrap-up video giving my rankings of the Myst games. The original (bearing in mind this was before Myst '21 was even announced, and I played the original Masterpiece Edition) ranked 3rd for me, with the top spot, after spending a long time in my mind tied with Riven, eventually going to Exile. But I'd say this version puts the original far closer to the top, perhaps even in a tie for second. Regardless, in this humble Myst fan's opinion anyway, it is the DEFINITIVE way to experience the original surrealistic adventure that will become your world.